- Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory | Journal of Neuroscience
- Prefrontal Cortex: From Synaptic Plasticity to Cognition
The synapsins and the regulation of synaptic function. Bioessays 12 : — CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects.
Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory | Journal of Neuroscience
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Prefrontal Cortex: From Synaptic Plasticity to Cognition
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The battery of tasks used in the present study was developed from previous research conducted to assess behavioral effects in the offspring of rats subjected to treatment with polyI:C during pregnancy.
As the offspring of polyI:C-treated dams display altered behavior in these tasks Howland et al. In general, behavior of the PEN-treated rats was similar to that previously reported for these tasks Ballendine et al. Therefore, it is likely that the relatively subtle manipulation of mPFC PNNs we performed was insufficient to disturb the global activity of this circuit. Previously, deficits in frontal-dependent object recognition tasks, including object-in-place and CMOR, were observed in the male offspring of polyI:C treated dams Howland et al.
Other tasks, such as object recognition or the tactile and visual variants of the CMOR battery, were unaffected Howland et al. The circuitry involved in the object oddity task is incompletely characterized, although no study to our knowledge has directly implicated the mPFC in this task. Previous work has shown the involvement of lateral cortical regions including perirhinal cortex in object oddity tasks Bartko et al.